Paintings by Marvin Cone, John Steuart Curry, William Bunn, and Alma Held have been added to the Regionalist Collection in recent years. These artists were all contemporaries of Grant Wood, and they all focused on local subjects. Cone, Bunn, and Held were Iowans with direct connections to Wood. John Steuart Curry, Grant Wood, and Thomas Hart Benton are three major practitioners of American Regionalism, a reaction against European modernist trends. In addition to these, paintings by John Noe and Carl Flick (both Iowa artists with their own connections to Grant Wood) are also featured.
Other featured acquisitions include photography of the Mississippi River by Randy Richmond, a drawing from Peter Mar Quality Toys, a Mississippi River painting by Audrey Brown, a drawing by Barbara Fedeler, perfume bottles belonging to Laura Musser McColm, a Roach and Musser factory whistle, a painting of the Mississippi River by Jonas Olof Grafstrom, a painting by Hans Breder, and other items. Many of the works of art and objects have been directly gifted. In other instances, individuals and families have made financial donations enabling the purchase of specific items.